{"id":5738,"date":"2024-12-11T18:24:17","date_gmt":"2024-12-11T18:24:17","guid":{"rendered":"https:\/\/mnitf.org\/?page_id=5738"},"modified":"2024-12-11T18:25:55","modified_gmt":"2024-12-11T18:25:55","slug":"funded-grants-2019","status":"publish","type":"page","link":"https:\/\/mnitf.org\/es\/funded-grants-2019\/","title":{"rendered":"Funded Grants &#8211; 2019"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"vc_empty_space\"   style=\"height: 3em\"><span class=\"vc_empty_space_inner\"><\/span><\/div><\/div><\/div><\/div><\/div><div data-vc-full-width=\"true\" data-vc-full-width-init=\"false\" class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><h2 style=\"text-align: center;font-family:Open Sans;font-weight:600;font-style:normal\" class=\"vc_custom_heading vc_do_custom_heading\" >FUNDED GRANTS - 2019<\/h2><div class=\"vc_empty_space\"   style=\"height: 2em\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p class=\"font_8\"><strong>UNITED NETWORK FOR ORGAN SHARING\u200b<\/strong><\/p>\n<p class=\"font_8\"><em>Genetic and Immune Predictors of Recurrent Glumerulonephritis of the Kidney Allograft<\/em><\/p>\n<p class=\"font_8\">The project seeks to quantify the association between kidney-specific prognostic measures (biopsy findings, renal anatomy characteristics, machine perfusion parameters) and long-term post-transplant graft outcomes to reduce risk aversion among physicians evaluating kidneys for transplantation and to provide greater resources for decision-making, thus reducing kidney discards and improving clinical outcomes in transplantation. The project contributes to scientific knowledge relative to biopsy findings regarding renal anatomy and pulsatile perfusion parameters.<\/p>\n<p class=\"font_8\">Principal Investigator: Darren Stewart, MS<br \/>\nAwarded:\u00a0 September 2019<br \/>\nDuration: \u00a024 months<br \/>\nAmount of Award: \u00a0$100,000<\/p>\n<p class=\"font_8\"><strong>\u200bBRIGHAM &amp; WOMEN&#8217;S HOSPITAL<\/strong><\/p>\n<p class=\"font_8\"><em>\u200bDonate HCV Trial: Donors of Hepatitis C NAT Positive Allografts for Transplantation Evaluation in Non-HCV Recipients<\/em><\/p>\n<p class=\"font_8\">The objective of this trial is to continue to expand the organ donor pool by demonstrating that hearts, lungs, kidneys, and dual organs can be transplanted safely and efficaciously from donors who are infected with Hepatitis C virus (HCV) into recipients who are uninfected. The Grantee will use a shortened, 2-week, prophylactic course of HCV medications in order to block viral replication in the recipient. The primary outcome is a composite of a sustained virologic response at 12 weeks after completion of antiviral therapy for HCV infection and graft survival at 6 months after transplantation.<\/p>\n<p class=\"font_8\">Principal Investigator:\u00a0 Ann Woolley, MD, MPH<br \/>\nAwarded:\u00a0 September 2019<br \/>\nDuration:\u00a0 24 months<br \/>\nAmount of Award:\u00a0 $149,996<\/p>\n<p class=\"font_8\"><strong>\u200bUNIVERSITY OF PENNSYLVANIA<\/strong><\/p>\n<p class=\"font_8\"><em>\u200bEx Vivo Human Limb Preservation for Vascularized Composite<\/em><\/p>\n<p class=\"font_8\">Battlefield injuries are less deadly with modern advances in body armor, rapid evacuation from the field, quick clot dressings, tourniquets, and vascular shunts. These have led to higher warrior survival rates, but amputation rates for massive blast injuries remain high. Alternatives to discarding an amputated limb in forward areas of combat would have a direct impact on our wounded warriors. The Grantee proposes an alternative treatment for an amputated extremity: preserving the human limb temporarily out of the body (or \u201cex vivo\u201d) with perfusion technology until more resources are available for surgery. Such technology could also be used in traumatic amputations from civilian injuries and mass casualty scenarios. This research proposal aims to develop a laboratory human model to temporarily preserve a severed human limb or part of a limb for delayed replantation, for use in surgical reconstruction, or in preparation for human limb transplantation.<\/p>\n<p class=\"font_8\">Principal Investigator: L. Scott Levin, MD, FACS<br \/>\nAwarded: February 2019<br \/>\nDuration: 12 months<br \/>\nAmount of Award: $100,000<\/p>\n<p class=\"font_8\"><strong>\u200bIVIVA MEDICAL, INC.<\/strong><\/p>\n<p class=\"font_8\"><em>Bioengineered Pancreas for Diabetes Treatment<\/em><\/p>\n<p class=\"font_8\">Approximately 25% of patients suffering from diabetes are completely dependent on insulin supplementation, which is provided through exogenous insulin injection or islet transplantation. The Grantee\u2019s goal is to build grafts that will overcome challenges faced by current transplantation approaches. The Grantee will design a hierarchical channel network with geometry optimized for perfusion and diffusion of molecules. The Grantee will optimize the membrane\u2019s composition, mechanical, and physical properties to mimic the native islet niche. After optimization of the principal components and design, the Grantee will perform in-vitro and in-vivo testing to evaluate graft survival and function. If successful, completion of the proposed project will provide a novel yet easily translatable technique to transplant human islets.<\/p>\n<p class=\"font_8\">Principal Investigator: Harald Ott, MD, CSO<br \/>\nCo-Investigator: Maria Jaramillo, PhD<br \/>\nAwarded: February 2019<br \/>\nDuration: 12 months<br \/>\nAmount of Award: $150,000<\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div class=\"vc_row-full-width vc_clearfix\"><\/div><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"vc_empty_space\"   style=\"height: 3em\"><span class=\"vc_empty_space_inner\"><\/span><\/div><\/div><\/div><\/div><\/div><div data-vc-full-width=\"true\" data-vc-full-width-init=\"false\" class=\"vc_row wpb_row vc_row-fluid vc_custom_1474543056562 vc_row-has-fill\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div id=\"sc_call_to_action_789172264\" class=\"sc_call_to_action sc_call_to_action_accented sc_call_to_action_style_2\" data-animation=\"animated  normal\" style=\"width:100%;\"><div class=\"sc_call_to_action_info\"><h2 class=\"sc_call_to_action_title sc_item_title sc_item_title_without_descr\">\u00a1Ay\u00fadanos a salvar y mejorar las vidas de quienes padecen una enfermedad org\u00e1nica en etapa terminal!<\/h2><\/div><div class=\"sc_call_to_action_featured\"><div class=\"featured_bg\" style=\"background-image:url(https:\/\/mnitf.org\/wp-content\/uploads\/2016\/09\/call_bg.png);\"><\/div><\/div><div class=\"sc_call_to_action_buttons sc_item_buttons\"><div class=\"sc_call_to_action_button sc_item_button\"><a href=\"\/es\/ways-to-give\/\" data-animation=\"animated  normal\" class=\"sc_button sc_button_square sc_button_style_filled3 sc_button_size_large\">DONAR<\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"vc_row-full-width vc_clearfix\"><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"FUNDED GRANTS - 2019 UNITED NETWORK FOR ORGAN SHARING\u200b Genetic and Immune Predictors of Recurrent Glumerulonephritis of the Kidney Allograft The project seeks to quantify the association between kidney-specific prognostic [...]","protected":false},"author":990002,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-5738","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Funded Grants - 2019 - Mendez National Institute of Transplantation Foundation (MNITF)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mnitf.org\/es\/funded-grants-2019\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Funded Grants - 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